CONCEPT, DESIGN AND IMPLEMENTATION OF A CARDIOVASCULAR GENE-CENTRIC 50 K SNP ARRAY FOR LARGE-SCALE GENOMIC ASSOCIATION STUDIES.

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS).True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of div

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The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells

Abstract YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers.In tumor cells, Fairy Wings they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.In fewer cases, they have also been shown to

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Re-working the Past: Evidence for Late Neolithic and Early Bronze Age Flint Extraction at the Early Neolithic Mines of Sussex

This paper will summarise evidence for Late Neolithic and Early Bronze Age flint extraction at the Southern English mines, beginning with a brief synopsis of their chronology and BATH BOMB REVIVAL followed by a summary of mine lithics.It is argued that understanding later mining is equally important as examining its beginning, because the Neolithic

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